agºÍ¼Ç

À´Ô´£º²èÒ¶µ°Í¼Æ¬ £¬×÷Õߣº  £¬£º

ÎÒ¸úÄ㽲࣠£¬¹ðÁÖÈËÏеÃÎÞÁÄ £¬È¥²èɽվ½ÖÉ¢ÐÄÄÇÊÇѰ³£Ê¡£ÔçÉÏÞß¿­Ñô¹âÈ÷µÃÂúµØ £¬ÍíÉÏÓÖÊǵƹâÉÁÉÁ £¬±ðÓÐÒ»·¬×Ìζ¡£¿ÉÎÊÌâÀ´ÁË £¬²èɽվ½Ö¾¿¾¹Êǰ×Ìì¿ËºÃ £¬ÕÕ¾ÉÍíÉϸüÓаå·£¿½ñÌìÎÒÃǾÍÀ´³¶³¶Õâ¸ö»°Ìâ £¬ÀÌÀÌÀïÃæµÄ¡°½²¾¿¡±¡£

°×ÌìÕ¾½Ö £¬¾°ÎïºÍÇå¾»ÊÇÁÁµã

Õâô¸úÄã½²¿© £¬°×Ìì¿Ë²èɽվ½Ö £¬×îÖ±½ÓµÄÀûÒæ¾ÍÊǾ°ÎïÆ¯ÁÁ¡£ÓÈÆäÊÇÄêÁäÌì £¬Ì«Ñô¹âůÑóÑóµØÈ÷ÔÚ²èÊ÷ÉÏ £¬ÄÇÂÌÓÍÓ͵ÄһƬ¿´µÃÈËˬÉñ¡£ÔÙ¼ÓÉÏÔçÉÏÈËûÄÇô¶à £¬ÊʺÏÅÄÕÕÁôÄî £¬»òÕß·¢¸öÅóÓÑȦװװ°å·¡£Äã·¢Ã÷û £¬°×ÌìµÄ²èɽվ½ÖÁíÓиöÀûÒæ £¬¾ÍÊÇ¿ÕÆøÇåР£¬Äñ½ÐÉùÁ¬×ÅÒ»ÉùÓÖÒ»Éù £¬ÌرðÀÌÐÄ¡£

ʵÓÃСÌùÊ¿£º°×Ìì¿Ë²èɽվ½Ö £¬¼ÇµÃ´øÃ±×Ó»òÕß·Àɹ˪ £¬ÓÈÆäÏÄÌì £¬Ì«Ñô¶¾µÃºÜ¡£

Ò¹ÍíÕ¾½Ö £¬ÈÈÄÖºÍÆø·Õ¸üÓÐζ

½²»ØÀ´ £¬ÍíÉϿ˲èɽվ½ÖÓÖÊÇÁíÒ»ÖÖÌåÑé¡£µÆ¹â´òµÃƯÁÁ £¬ÓÈÆäÊǽڼÙÈÕ £¬ÄÇ¿­µÄµÆÊλ¹¸ãµÃÂùÓд´Òâ¡£ÄãÏþµÃû £¬ÍíÉÏÈËÆøÍú £¬Þß¿­µÄС̯··¡¢ÂôÊÖ¹¤ÒÕµÄ £¬ÉõÖÁÓÐЩÂôС³ÔµÄ¶¼°ÚÆðÀ´ÁË £¬Æø·ÕÈÈÄֵúÜ¡£Èç¹ûÄãÊÇϲ»¶´ÕÈÈÄÖµÄÄÇÖÖ £¬ÍíÉÏÞß¿­¹äһȦ £¬²»µ«¿ÉÒÔÕ¾½Ö £¬»¹¿ÉÒÔ³¢µãÍâµØÐ¡³Ô £¬¿Ð¸ö¹ðÁÖÃ×·Û¶¼³É¡£

°×ÌìºÍÍíÉÏ £¬Äĸö¸üÊʺÏÄ㣿

ÎÒ¹À¶Ñ°¡ £¬ÕâµÃ¿´Äã¸öÈ˵ÄϲºÃ¡£Ï²»¶Æ½¾²µÄ £¬°×Ìì¿Ï¶¨ÊǸüÊʺÏ£»Ï²»¶ÈÈÄÖµÄ £¬ÄÇÍíÉÏÈ¥¾ÍûÅÜÁË¡£²»¹ýҲҪעÒâ £¬ÍíÉÏÈ˶à £¬Í£³µ¿ÉÄܲ»±ãµ± £¬°×ÌìµÄ»°·´¶øÈÝÒ×ÕÒµ½Î»Öá£ËùÒÔ £¬Èç¹ûÄãÊÇ×Ô¼ÝÒÑÍùµÄ £¬¿ÉÄܸüÊʺϰ×Ìì¿Ë¡£

Ïà¹ØÍ¼Æ¬
³£¼ûÎóÇø£ºÐí¶àÈËÒÔΪվ½ÖÍíÉϲÅÓÐÒâ˼ £¬Æäʵ°×ÌìÓв»ÉÙÆæÌصľ°Îï £¬Ö»ÊÇÄãû·¢Ã÷¡£
Ïà¹ØÍ¼Æ¬

ÄǾ¿¾¹Òª¸ü×ÓÑ¡²Åû²È¿Ó£¿

¼òµ¥½² £¬Èç¹ûÄãÊÇÅÄÕÕ´ò¿¨ £¬°×Ìì¿Ë£»Ïë¸ÐÊÜÈÈÄÖÆø·Õ £¬ÍíÉÏÈ¥¡£×Լݵϰ £¬°×ÌìÍ£³µ¸ü±ãµ±¡£×ÜÖ®Ò»¾ä»° £¬¿´Äãϲ»¶É¶ £¬¾Íѡɶ¡£

²èɽվ½Ö, °×ÌìÓÎÍæ, Ò¹ÍíÓéÀÖ, ¹ðÁÖÂÃÓÎ, Õ¾½Ö¹¥ÂÔ

Ïà¹ØÍ¼Æ¬

¡¶Ð¢¸Ð×î×ÅÃûÈý¸öÏï×Ó¡·

ÂÞÀ³Éú»îÊÇÖйú¼Ò·ÄÐÐÒµÁúÍ·ÆóÒµ £¬¾Û½¹¡°³¬ÈᴲƷ¡±¶¨Î» £¬¼ùÐÐ¶àÆ·ÅÆ¡¢È«ÇþµÀÉú³¤Õ½ÂÔ £¬ÇÒºã¾Ãά³Ö¸ß±ÈÀý·Öºì £¬¹É¶«»Ø±¨Óźñ¡£¹«Ë¾ÆìÏÂÓµÓÐÂÞÀ³¡¢ÂÞÀ³¶ùͯ¡¢LOVO¡¢ÀÈÍå¡¢ÄÚÒ°¼°À³¿ËÐÇ¶ÙµÈ¶àÆ·ÅÆ¾ØÕó £¬ÁýÕÖ³¬¸ß¶ËÖÁ¹«¹²Ïû·ÑÊг¡¡£½üÄêÀ´ £¬¹«Ë¾»ý¼«Íƽø¡°¸÷ÈË·ÄС¼Ò¾Ó¡±³¡¾°»¯½á¹¹ £¬²¢×Ô2024ÄêÆðÏµÍ³ÍÆ½ø´óµ¥Æ·±¬Æ·Õ½ÂÔ £¬ÍƳö¡°ÁãѹÉî˯Õí¡±¡°ÎÞºÛ°²Ë¯´²óÒ¡±µÈÃ÷ÐDzúÆ· £¬¾«×¼ÇÐÈ빦ЧÐÔ˯ÃßÈüµÀ £¬ÀÖ³ÉʵÏÖ´ÓÇþµÀÇý¶¯Ïò²úÆ·Çý¶¯µÄÕ½ÂÔתÐÍ¡£

¡¶½­Ãż¦ÎѹŽ֡·

µ«¹ØÓڵ°îÀ´ËµÎÞÂÛ¾»ÖÃ÷ÈÕÇ·ù¼¸¶à £¬ÖÎÀí·ÑÊÇʵʵÔÚÔÚÕÇÁË16±¶ÁË¡£

¡¶Î÷°²ÄêÇáÅ®ÍÞ¶àµÄ´å×ÓÊÇÄĸö´å¡·

ÆäÒ» £¬´´Á¢¶àÖÖ¸ßÇø·ÖÂÊ¡¢µÍ±¾Ç®¡¢¸ß¾«¶ÈµÄÈýά»ùÒò×éѧ¼¼ÊõÌåϵ¡£Ñз¢ÁËȾɫÖʹ¹Ïó²¶»ñм¼ÊõDLO Hi-C¼°µ¥Ï¸°ûsciDLO Hi-C £¬ÊµÏÖÔÚµ¥Ï¸°ûÇø·ÖÂÊÏÂȾɫÖÊ»¥×÷µÄ¶¯Ì¬½âÎö £¬²¢½ÒʾÃâÒß¼¤»îÀú³ÌÖÐȾɫÖʽṹÓò½çÏÞÖØ×é¼ÍÂÉ¡£Æä¶þ £¬½Òʾ²¡Ô­-ËÞÖ÷»¥×÷ÖеÄÔ¶³Ìµ÷¿ØÐ»úÖÆÓëDZÔÚ¸ÉÔ¤°Ðµã¡£Ê״η¢Ã÷²¡¶¾¿É½èÖúËÞÖ÷ת¼Òò×ӽ鵼²¡¶¾DNAÓëËÞÖ÷ȾɫÖÊ»¥×÷ £¬²¢ÀûÓÃËÞÖ÷RNA Pol IIÍê³É×ÔÉíת¼£»ÊµÑé֤ʵRUNX1ÒÖÖÆ¼Á¶Ôα¿ñÈ®²¡¶¾£¨PRV£©¸´ÖÆÒÖÖÆÐ§Âʿɴï60% £¬Îª¿¹²¡¶¾Ò©Î↑·¢Ìṩае㣻ÔÚ½áºËѬȾÑо¿ÖÐ £¬Ìá³öLRRK2¿É×÷Ϊ½áºË¸Ë¾úѬȾеÄDZÔڰеã¡£ÆäÈý £¬¹¹½¨¶àÌõÀí½á¹¹ÆÊÎöËã·¨Ó뿪·Å¹²Ïí×ÊԴƽ̨¡£½¨Á¢ÍØÆË½á¹¹Óò£¨TAD£©½çÏÞ¼°Ç¿¶ÈÔ¤²âÄ£ÐÍpTADS£»Ñз¢È¾É«ÖÊ»·Êý¾Ý¿âChromLoops £¬ÁýÕÖ13¸öÎïÖÖ¡¢1030×éÊý¾Ý £¬ÀÛ¼ÆÐ§ÀÍÈ«Çò48¸ö¹ú¼ÒºÍµØÇø £¬»á¼ûÁ¿Í»ÆÆ1.3ÍòÈË´Î £¬ÏÔÖøÌáÉýÁËÎÒ¹úÔÚÈýά»ùÒò×éѧÊý¾Ý±ê×¼»¯ÆÊÎöÓë×ÊÔ´¹²Ïí·½ÃæµÄ¹ú¼ÊÓ°ÏìÁ¦¡£

ÍøÕ¾µØÍ¼